LOCUS       scaffold_933           15144 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  .
ACCESSION   scaffold_933
VERSION     scaffold_933
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.0.0
            Run date     :: 2025-04-15 23:30:40
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15144
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15144
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[9639:14598]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="30000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9640..14598
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="30000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..15144
                     /SMILES="NC(Cc1ccccc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15144
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /tool="antismash"
     CDS             complement(join(153..341,446..1171))
                     /locus_tag="4166214"
                     /transl_table=1
                     /translation="RASHSQGFSLIQSISLIPPFNRTSTAWQMGNKTDRARVESDISFG
                     QVMRKAWLSQMSDGLRILDWSCFFLSNQEGFHVLEFVKYSKMQSMSIRTFWWRGGSVII
                     GQFDFSWSLATEFEMVLKELKPTPGRPPYVMRKSRPLSVFETQDLCSLPRTPRSRFEDH
                     LKDVRGRLLQHRKSNLAELPCRGDEFSHRVLSVFATVNFSLMISISSIRRREGFSCGGF
                     RVASSHSHSRRSALSSKSSQDQNSARQLSRGKKNQSKIKQPHCETNSHGSNENIEEKPH
                     KPVNFSHHQRHNLSHATAPRMLH"
     CDS             3069..3632
                     /locus_tag="4166216"
                     /transl_table=1
                     /translation="MTMPFDTITTSATFASIFLSALPNGGETGVESVVTTVRAVTVPKT
                     NGPVSEATSTFRVTSESTSESTSTSRVTPESTSESTSTSRVTSQSIPRVTASIIASDPS
                     DRTSPVLATSSPTVPIASSPNTTRPTSNHSIAPGAAAGIGVGSAAAGALIAALIVWFIM
                     RKARKSPKIPNDDPGGSWLSSNTA"
     CDS             join(9640..12249,12304..14598)
                     /NRPS_PKS="Domain: PP-binding (10-65). E-value: 7.9e-07.
                     Score: 21.5. Matches aSDomain:
                     nrpspksdomains_4068962_PP-binding.1"
                     /NRPS_PKS="Domain: Condensation_DCL (296-469). E-value:
                     5e-29. Score: 93.2. Matches aSDomain:
                     nrpspksdomains_4068962_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (623-1007). E-value:
                     4.7e-80. Score: 261.0. Matches aSDomain:
                     nrpspksdomains_4068962_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1108-1179). E-value: 1.2e-10.
                     Score: 33.3. Matches aSDomain:
                     nrpspksdomains_4068962_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1207-1464). E-value:
                     2.7e-28. Score: 90.7. Matches aSDomain:
                     nrpspksdomains_4068962_Condensation_LCL.1"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     249.1; E-value: 1.1e-75)"
                     /gene_kind="biosynthetic"
                     /locus_tag="4068962"
                     /sec_met_domain="Condensation (E-value: 2.9e-28, bitscore:
                     86.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-81, bitscore:
                     260.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.9e-10, bitscore:
                     28.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDFLVLKELCLTLQTEFSQLDLDASFIHHGGHSLTAAALVAACKA
                     QGCELTTGKVLTSDSLRNLIHSAQPCAKPDSPDPVSKQVSSTYMGTPSRESSILSKLSR
                     NLRYQNDNMTPPEPDDFLSQKSLTLSPVTLNQIRSHALADSPSPSPERSSTPTSIEITS
                     TLKRHSISSPQRLNASSLGSLSFPERHDDKLTEMQLSLIHGTLKTPGMNIITHCETYYS
                     HYIPTMKAAWKTVVEMEPIFQVLPLKKFLEEDRKVFDWRDATAVEEGDEKDGKGLCDEN
                     RIGSFFRVVPCTVAPKQLSRSKIIWIVHHSLIDGYSASLVFDKVRRVANGMSVQPGPPF
                     SRLAEDLRLFQQSHRDEGNAYWLKKLEQSNDAKTELLLPYVDEDAGQARNAEVVSDLSS
                     VVEKLRSAARDMNVTPAAFFNAAWALVLATYADSDMVAFGAVLSGRNLPLPNVAAVVGP
                     LVNTLPLYVNINRSLSVQEFVRSVFENLMELAEFQWTTPEHGFSRSFESALSMQFGPPD
                     PLQAAVMPIESPYTHQATEIPLSIAVEADGKLRFQYHRNRFSPKNIGKLVSCYEEALQL
                     LLQAHATVDATMEGLLSCPSKAVLGRYGNCFSGLTTKTSVKRDLVTLFEATAQKFPDDI
                     AIERGDFSITYRDFDHVSSRLALRLTRLISTGDVVCVHSDRSVNWLIAIYSILKAGGVY
                     CSLDSALPPDLRNSMYSLADAKVYLTPSTSQLHLTPVDCELYMSVESALSEFDDPEVGV
                     LEHRQQPMPSSTAYLCFTSGSTGTPKGVLCTHEGLVAFQSDLEVRLFAQPGKKISQIMS
                     AAFDGSIHELFSALSYGATLVLQAGGDPFAHLHSVDSAILTPSIARVLNPEDFKRLSTV
                     YLVGEPVPQAVADKWSNHKQLYNMYGPTEGTCGATIKRLNPASPVTIGGPNPTTRIYLL
                     NSRKDMVLPGMIGEIYLAGVQIAKGYLNLPTETKDRFLPDTICRNGEQMYKTGDRGYWN
                     ELGEIVCLGRNDRQIKLRGYRLDMNDLEIRIAKAMPTMEGIAISRRGDHLVAMVQPASM
                     NTKDLLSRVAKVIPSYAIPQQITAVDRLPTTSAGKIDYAAVSRNSIGSPTCQKGAPRTA
                     TERAVASVFNSVLNLGEGTRVTLGSSFVDLGGHSLQQLSLAKHLTRIFDLQIPLRLIIE
                     RPALGELAKGIDDHKATNKPAMPPAHSLGQQQVSPIEKEWLQKYDVDAGSSCFNVAFIS
                     SFAEETVDRYVLAEAWNTVLARHKLLRSKYVPRRARPPLRSYASCAPQAQRVGNLDLWT
                     EVNRPFQVGRTNPARVTVTKDRLIVVLSHIVADYTTLAILLREASAVYNGQQLEPISRS
                     YSDVDVWYRNVPPCYLDFWSTFLKDCPDSPPLLGRHQERSGCRGVSTVSSIDSHAFQEM
                     LQYSHSAKVSLQQLVTGAVAICLQLDSPETDIVIGNPYMNRNSDEDLETVGLFLEPLPV
                     RIKYGLGPDETSDDIPETYMQAVQRSSQAALANAMPWHRLLDHLSIHPTYPDHPLLDVM
                     VSFHDYRQSLDLKMAGPDFESCFVWSEGSKFKLMCEFTVISDTKLLLRLEHDTECISAA
                     EIQRIQTLIPQALSLLSQSIPHNELKRRLFAGEEPTCHQVMDTDQLFGTRLCDIE"
     aSDomain        9670..9834
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_4068962_PP-binding.1"
                     /evalue="7.90E-07"
                     /label="4068962_PP-binding.1"
                     /locus_tag="4068962"
                     /protein_end="65"
                     /protein_start="10"
                     /score="21.5"
                     /tool="antismash"
                     /translation="LTLQTEFSQLDLDASFIHHGGHSLTAAALVAACKAQGCELTTGKV
                     LTSDSLRNLI"
     aSDomain        10528..11046
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_4068962_Condensation_DCL.1"
                     /evalue="5.00E-29"
                     /label="4068962_Condensation_DCL.1"
                     /locus_tag="4068962"
                     /protein_end="469"
                     /protein_start="296"
                     /score="93.2"
                     /tool="antismash"
                     /translation="KQLSRSKIIWIVHHSLIDGYSASLVFDKVRRVANGMSVQPGPPFS
                     RLAEDLRLFQQSHRDEGNAYWLKKLEQSNDAKTELLLPYVDEDAGQARNAEVVSDLSSV
                     VEKLRSAARDMNVTPAAFFNAAWALVLATYADSDMVAFGAVLSGRNLPLPNVAAVVGPL
                     VNTLPLYVNI"
     aSModule        10528..13230
                     /complete
                     /domains="nrpspksdomains_4068962_Condensation_DCL.1"
                     /domains="nrpspksdomains_4068962_AMP-binding.1"
                     /domains="nrpspksdomains_4068962_PCP.1"
                     /locus_tags="4068962"
                     /monomer_pairings="Phe -> Phe"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       10561..10614
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4068962_0001"
                     /evalue="1.40E-04"
                     /label="C3_starter_134-155"
                     /locus_tag="4068962"
                     /protein_end="325"
                     /protein_start="307"
                     /score="14.9"
                     /tool="antismash"
                     /translation="VHHSLIDGYSASLVFDKV"
     CDS_motif       10945..11034
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4068962_0002"
                     /evalue="4.70E-10"
                     /label="C5_DCL_263-294"
                     /locus_tag="4068962"
                     /protein_end="465"
                     /protein_start="435"
                     /score="31.9"
                     /tool="antismash"
                     /translation="VAFGAVLSGRNLPLPNVAAVVGPLVNTLPL"
     aSDomain        join(11509..12249,12304..12714)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_4068962_AMP-binding.1"
                     /evalue="4.70E-80"
                     /label="4068962_AMP-binding.1"
                     /locus_tag="4068962"
                     /protein_end="1007"
                     /protein_start="623"
                     /score="261.0"
                     /specificity="substrate consensus: Phe"
                     /tool="antismash"
                     /translation="FEATAQKFPDDIAIERGDFSITYRDFDHVSSRLALRLTRLISTGD
                     VVCVHSDRSVNWLIAIYSILKAGGVYCSLDSALPPDLRNSMYSLADAKVYLTPSTSQLH
                     LTPVDCELYMSVESALSEFDDPEVGVLEHRQQPMPSSTAYLCFTSGSTGTPKGVLCTHE
                     GLVAFQSDLEVRLFAQPGKKISQIMSAAFDGSIHELFSALSYGATLVLQAGGDPFAHLH
                     SVDSAILTPSIARVLNPEDFKRLSTVYLVGEPVPQAVADKWSNHKQLYNMYGPTEGTCG
                     ATIKRLNPASPVTIGGPNPTTRIYLLNSRKDMVLPGMIGEIYLAGVQIAKGYLNLPTET
                     KDRFLPDTICRNGEQMYKTGDRGYWNELGEIVCLGRNDRQIKLR"
     CDS_motif       11935..11994
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4068962_0003"
                     /evalue="7.90E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="4068962"
                     /protein_end="785"
                     /protein_start="765"
                     /score="27.6"
                     /tool="antismash"
                     /translation="AYLCFTSGSTGTPKGVLCTH"
     CDS_motif       12508..12594
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4068962_0004"
                     /evalue="6.60E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="4068962"
                     /protein_end="967"
                     /protein_start="938"
                     /score="34.4"
                     /tool="antismash"
                     /translation="PGMIGEIYLAGVQIAKGYLNLPTETKDRF"
     CDS_motif       12679..12744
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4068962_0005"
                     /evalue="1.20E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="4068962"
                     /protein_end="1017"
                     /protein_start="995"
                     /score="21.0"
                     /tool="antismash"
                     /translation="CLGRNDRQIKLRGYRLDMNDLE"
     aSDomain        13018..13230
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_4068962_PCP.1"
                     /evalue="1.20E-10"
                     /label="4068962_PCP.1"
                     /locus_tag="4068962"
                     /protein_end="1179"
                     /protein_start="1108"
                     /score="33.3"
                     /tool="antismash"
                     /translation="ERAVASVFNSVLNLGEGTRVTLGSSFVDLGGHSLQQLSLAKHLTR
                     IFDLQIPLRLIIERPALGELAKGIDD"
     aSDomain        13315..14085
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_4068962_Condensation_LCL.1"
                     /evalue="2.70E-28"
                     /label="4068962_Condensation_LCL.1"
                     /locus_tag="4068962"
                     /protein_end="1464"
                     /protein_start="1207"
                     /score="90.7"
                     /tool="antismash"
                     /translation="QKYDVDAGSSCFNVAFISSFAEETVDRYVLAEAWNTVLARHKLLR
                     SKYVPRRARPPLRSYASCAPQAQRVGNLDLWTEVNRPFQVGRTNPARVTVTKDRLIVVL
                     SHIVADYTTLAILLREASAVYNGQQLEPISRSYSDVDVWYRNVPPCYLDFWSTFLKDCP
                     DSPPLLGRHQERSGCRGVSTVSSIDSHAFQEMLQYSHSAKVSLQQLVTGAVAICLQLDS
                     PETDIVIGNPYMNRNSDEDLETVGLFLEPLPVRIK"
     CDS_motif       13390..13452
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4068962_0006"
                     /evalue="5.60E-04"
                     /label="C2_DCL_024-062"
                     /locus_tag="4068962"
                     /protein_end="1253"
                     /protein_start="1232"
                     /score="12.2"
                     /tool="antismash"
                     /translation="DRYVLAEAWNTVLARHKLLRS"
     CDS_motif       13630..13689
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4068962_0007"
                     /evalue="2.60E-03"
                     /label="C3_dual_135-156"
                     /locus_tag="4068962"
                     /protein_end="1332"
                     /protein_start="1312"
                     /score="10.9"
                     /tool="antismash"
                     /translation="HIVADYTTLAILLREASAVY"
     CDS_motif       13990..14079
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_4068962_0008"
                     /evalue="4.50E-05"
                     /label="C5_LCL_267-296"
                     /locus_tag="4068962"
                     /protein_end="1462"
                     /protein_start="1432"
                     /score="16.0"
                     /tool="antismash"
                     /translation="DIVIGNPYMNRNSDEDLETVGLFLEPLPVR"
ORIGIN
        1 ggaagaggtt ttatatgtgg tttttttctt ttttgctagg ggaggggggt gatgggggtg
       61 gaaggaaggg aggggggaga ggtattagaa gacccttggt atctttttct gtgcgtttgc
      121 tagggagctc tccgcttttt gatgtgtttg tatcaatgga gcattcttgg ggctgtagcg
      181 tgcgacaggt tgtgccgttg gtggtgggag aagttcacgg gcttgtgggg tttctcttcg
      241 atattctcat ttgatccatg actattcgtt tcgcaatgag gctgttttat ttttgactgg
      301 tttttctttc ctcgcgagag ttgcctcgcg ctgttttgat cctgagtagt attaatagag
      361 agttctgaag ggtttcgatg gcttgcggag gagtgggatt ggggaataaa tgaatggttt
      421 tttgatgcag agaggggttc tttacttgac ttgattttga agaaagggca ctccgtcgag
      481 aatgactgtg agaagatgca acgcgaaacc ctccacaaga aaagccttct cgtctccgaa
      541 ttgaactgat tgaaatcatc aaagaaaaat tcacagtcgc gaacacggac aggactcgat
      601 gtgagaactc atcccctcgg cacggtaact ctgcgaggtt tgatttccga tgttggagca
      661 agcgccctcg cacgtctttg agatgatcct caaagcgact tcgcggagtt cggggaagtg
      721 agcaaagatc ttgcgtttcg aatactgaca aagggcggga ctttctcata acgtaaggcg
      781 gacggccagg tgttggtttc aattccttca agaccatctc aaactccgtt gccaacgacc
      841 acgaaaaatc gaactgtcca ataataacgc ttccccctct ccaccaaaac gttctgatac
      901 tcatactctg catttttgaa tatttgacaa attctaatac atgaaatcct tcttggtttg
      961 aaagaaaaaa acaactccaa tccaatattc ttaacccgtc agacatttga gaaagccagg
     1021 ctttcctcat cacctgacca aacgatatat cgctctccac cctcgcccga tctgtcttgt
     1081 ttcccatttg ccatgccgtg gaggttctgt tgaaaggtgg tataaggctt atagattgaa
     1141 tgagggagaa gccctgacta tgtgaagccc tgactatgta gatggggagt catagtaaac
     1201 gctagctaag ggggtgcgca ctaaggtttc agcgagtctc acattgggca agatctctag
     1261 ccacactaat gaaagtgcac cactgaggct atgtagccgt gtgactgaat ttcagcaggt
     1321 tcaccttcct aagcgtcgat atcaaggatt ggcccagcct ttgaacggtg gagcgagcgc
     1381 atgttgactc gcaaaagcgg tcaaagaggc tttagaaaaa gcgccctggg ttagctacgt
     1441 ttgagtttgt aagtttgggg agggggttgg ggatgaggag gacggatgaa ttaacggtag
     1501 attgtgttta ttccaaaaga aagatcactt gtcttcttcc tagcaggagc gactagtgta
     1561 ttggtgactc tcggtgtgat cttcagcatc tcgcaatatg gcgattcagg attcaaaatg
     1621 atctcctgtc gggatgtgga tgatacgtat cagtcacagc aagatgagat ggatgaaaga
     1681 tagatgaatg attgatggat ctatcgagaa gaatgaatga tagagggatc gagagagcga
     1741 gcatctatct agaaaagaat atgaggatga ggatatctgt gtgggcacta gtgccctacc
     1801 actgatatcg tgacatctcc ctttcccact tcgcatcaga cgcgaaaatc tgttatcgcc
     1861 gacggcttcc atgttgctgg cgcgccaact atgaagtcaa aatttcgccc cgataattat
     1921 gccacgaggt tcgcagctgc gctaccttta gcgtaaactc aatcagcaca acagccgcaa
     1981 gtagttcccg actatctagt gccatccggt tcttgtctac ttcttatcga ctttcatcga
     2041 cgggctacac atcaggctct gaatctgatg gctgattgta tgtttcacat caactgccga
     2101 ctgtgtactt tttacagggt atttctgatc caaagacggc ggcaatggta agtcccactc
     2161 ttttccttcc ggcactccag ccactatcaa gcgtctagat taaacttgtg cttgagcccc
     2221 acgacctgcg agtagataag tctgccagga tatttcctgc agtggttcac gctcgttcta
     2281 tattcaattt tctaacttca atttatctct tctatatttt tttttctaca agacactgtt
     2341 tggggaattt ttgtgactgt cctgtctctc tgatgtctgt agcccatttg ctggtgaatt
     2401 ggactgtttt cggcttatag gcacctcgcc taactctccg ggtttggttt aagtatgtca
     2461 gggggcaccc atcataatat ctgcttctga gtacgggata gctggtcgag acttttttta
     2521 aaccccccta agccgaaaat agttcatttg atcagcaaac ggaaaacgcc actgcatgat
     2581 gttgaacggt tgtggggaca cccttgccga tcgacttcct ccacccatcc catttcctct
     2641 tctcagttat gatattcagc tggccattca gccgaatcat aaatcagccc cagtcctcta
     2701 aggccccatg ctgagatgat tcacgccact ttgcggcaat gtgacggtcg tgcggttcca
     2761 aatcattccc cgcgaatcag ccgaacctag atatgtgtac caccacacca tgctcagcaa
     2821 tggccagaac ccatagttat cagagattta tcatggcggg ccttcccttc agctctgcct
     2881 tatttaattt aaaataaaat gcgttttccc ttgacttcgt acttgaatga gcttaacctc
     2941 gtctttctca tttggccttc tctacagagt actcttcaac ttctctcgct cggtgaaagc
     3001 gcacgactaa tatcataaag tcttgtgttc tctctgcaga gttttgatcc attctagctc
     3061 gttgaagcat gactatgcca ttcgatacta tcaccacgtc ggccactttt gctagtatct
     3121 ttctgagtgc acttcctaac ggcggcgaga ccggtgtgga gagcgtggta acaacagtcc
     3181 gggcggtaac tgttccaaag accaatggac ctgtctctga agctacatct actttcaggg
     3241 tcacttctga atctacctct gaatctacat ctacttcaag ggtcactcct gaatctacct
     3301 ctgaatctac atctacttca agggtcactt ctcaatctat tccaagggtc accgcaagca
     3361 tcatagcaag cgatccatct gatagaactt cgccggtcct agccacatca agtccgactg
     3421 ttcccatcgc gagctcaccc aatacgacaa gacccacatc caatcactcg attgcgcccg
     3481 gtgctgcggc tggtattgga gttggaagtg ctgccgccgg tgctctcata gctgctctta
     3541 tcgtgtggtt catcatgcgc aaagcacgga agagtccaaa gatccctaac gacgatcctg
     3601 gaggatcctg gttatcctcc aataccgctt gatacgttat ctaagaggtg tggtagcact
     3661 tggagtcgtt gttagcccag ccgttgggcg atcaaaaggt tttatttcga caatttacac
     3721 agaccatgtc cgacgccatt atcgaatatg agaagcggag ggagaggggg aggatagggg
     3781 gaggaagaag ataggaactt attattacag tttaaacccc actacatatt ttctcctcca
     3841 agacccccct gaacgattct ccgaaccaaa aaaaaatcaa cttgcaaacc ttccatccaa
     3901 tcctgctgtt ctcttctcac ctccgcattt taaaaaacgt caacatcgcc cctttttctt
     3961 gaaaatgaaa gagggttctc gaagcaggat tccgggaaac acaaaagagg gtttttttcc
     4021 ttttagtgtt tattgattgg agatacggtt ccgttcatga cagttcgaac atgaccggtt
     4081 tccgaggcct attccataag ataatggtgg gccgtcatcg ggtaggttgt tcataaagga
     4141 aagtgcgtga ccgaagtggt acgtaagaga aaaacggtga ccaaatacca gaagaaaaaa
     4201 cccccatttt cgctgttttg agaatggtta tattacgatc tagatttctc aatatgtatt
     4261 gcaagctggt caagcctaag attcactgat cgcttctcgt cggaatcaaa cagtcggctc
     4321 tgcgttcttc atcgagttct ttcgagtaag aaactccccc atacgatcaa ttggcacccc
     4381 ccccacaaaa agtaagtaag agaggtagta ggtacggctg taccaagaac cgattcacta
     4441 attatagttg tgcctagtgt accaactgat aagtcgatat cggccactgt gcataaccaa
     4501 aaatgaaagg gcgataaagc cgtatacgga gaaaaaacaa acctgggacc ggaaaaaagt
     4561 gtcttcagtg acgttaatga aatagtcatc tatcgacgtc tttccccgcc caacttccag
     4621 attcggacgc agctttctcc gggatctcac agctttgctc ctgttccatg gaattgaatc
     4681 gagaggtgat gtttcaccat ttcctcgtca ccttgatcca tgatttggag atattttccg
     4741 aaattgctgc tgatgctcat agcgcaaatc attccgaggt tctgaaatag catggcggat
     4801 agttgtggga cctgcagcct tgctttccac cccccttaat caaaatcgga cccccttagc
     4861 tctgtcttcc ttcatggaat tgattggcct tgtttgtcgt tccgaaagtt gtgtctagat
     4921 tccttttccg ttgagttttg gctgctgaag aattaagaac gtccctcgtt tttgggaatg
     4981 ggatgcactg atttaggctg cgctactgtt ccttcgatcc ccgtccccgc tcttgctatc
     5041 ttattgcttc cctgccgact ttcgacggaa tgtaaaaatg ccttctgaag cttttacagc
     5101 tttgtcaagt gaggtttttt tttggctgta ctttgcctag ctttgatccc aaatgatttt
     5161 gaacgattga tcggaggttg aggtcaccct ctctctttcg cttcttgttc ggcgacggag
     5221 ttgaattaac gtgttttctc ttttcaccga cttggatcgt ctcgtcggga ccttctgatt
     5281 cctctccaca gcgcactttt aaccaggaat tcggagactg tgttatctgc tgtatggtca
     5341 ttatcgagct tgctttccaa aatcccgcat ttgtgccttg tgagagagtg aagctagcct
     5401 ctagcctcct ccaaagctaa gtcgcattat ttggcggaag gccatgggga atggctagct
     5461 gccagggatt gagttctgcg ggtggaaata tttatatgta gtagtctcga ggagctatcc
     5521 tctttcttca ttcagacaga catttgttca ttcaagtatc gaagcaatct actaccttcc
     5581 ccccctacaa acaggtttat attaacctgc tgtatcgaag tatcgagtat ttgagtatag
     5641 caatacttcc tcacagtatt tgtgttggca atttgtggat tttttggtat ttctgtcctc
     5701 gattttgcaa gcaggagaat aaaacctacg tataaacccc atactacccc ttttcagcgc
     5761 agtgcgggca atttgcagtt gaaaaggtgc aaaaagactt gccgcaaagt taaggaaaca
     5821 tctctggacc acagcagtct gccatcgtca ccccgggatc aacgcaagca agcatgggca
     5881 cccgtccctc accaaaaaaa aacgccgacg gctgactaag agctacactg tactttatca
     5941 aatttttcaa ctgggcaaca ctgaaaccag cttaatatcc gagaggcgct tgtgacttca
     6001 atatctgcac ttttcgagtt gacagtgatg ctgttttcac cccttatact gcttcttcat
     6061 cacaattcac aaaccccttt gtcaagtact gcattcagtg cttgcttact ctgacataaa
     6121 atagagtagc ttcttagctt atgcttttac cgctggccct caaacttggc tgaataccta
     6181 accacctcac ggaaaagcat gtctaattat cgaagatagg agacgttaac gtcttgaaga
     6241 aataaaaaaa atgggtttac tagaccaagt tcatgcaggt tgctcaatgt ataaattatc
     6301 aggagtccat atgcccctac atatcttcta cccacatgtg cctgccgcct ttgctatctc
     6361 ggtcgctttt gatcctgttc taccttgccg ctgccccctt cttaacccca tatctcgttc
     6421 ccttcaactg ttttgttacc tgttcctatt gcccctggct ccatgtttta atcttgtaca
     6481 aattgcaccc gtatttttgc ccttctgctt cttctcatcc tctggctctc cctcgtcctc
     6541 ctacaccttc tcctcccgcg cggcctcagc ccccacccct ttttgtcttc tttctttttc
     6601 tttttcttgc cactcgctct ctctctcgga gctgtagcct cgtttgccga tgcatcaacg
     6661 catctcttcg tgccaatgcc ttttgtcttg ccgatgcttc tcttctcgcc aatgattgtt
     6721 ttcttgttgc caattcttgc tatacctact tttctcatgc ccgattctca tcacactgtg
     6781 gcagggagga atggggcgga gcggatgtgg cctgtccgtg gctgcttttt cccccccttt
     6841 ttgtgttagc ttgcttgttc tccgccttca ctcccttttc taaaacggtc tatacaagaa
     6901 ggatggaaga cttgcagggt cggaagtttt cagggtttct cttggagtca gttctttaat
     6961 tttctcctat gagtcagcga tactattgcc cctcaggggt ataagagagc aataataatg
     7021 tgtgctaggt ggatcagcga acacgacttc ctcgaaccag taaatcacac agagctcatt
     7081 taattccctc ttctttacct cttccaatta catttgctcc tgcagagcac cataagtttt
     7141 ccccgttcga ctcccactaa gtattccaaa ccccctactc ccttttcatt ctgacccctt
     7201 ttcctcctac ccttcttcat ccctccttac tatcgaaacc atttcgacca cttgcctgct
     7261 ctgcttctag gaatctcggt atttctcaac agtagattct agggtaaata atcaatgatt
     7321 atccccttga tttgagcatg actcaccaaa aacgaatatc ctacagagtg caataccatc
     7381 tttaccaatg acaaatgaaa atcaaaatac cctcgcctaa tatcctcagt ggctttttca
     7441 gaagtgtcac gctgctgccg ccgctggaaa cgaccctcga cgatgccctc ggtcacttag
     7501 ccagctctga caattctttc tctacccaaa attttgaaat cgactgtttc aaacttgaca
     7561 aagggcttag cagtttcgat tatattaaga ttgtagttgc tgttaaatct ggtaccaata
     7621 gcctacaaat actactttgg gggtgacttc gctgttctcg atgtactcca agctgacctg
     7681 gtatttctca cctgcttata tcaaaggttc caacctcacc ctacgcgcat catacagcga
     7741 ttcggaggat ccaatgatga tgatttatta cactattctt agctaaatag ctcatctagg
     7801 ggttctataa ttccgtgtag gaaaatagcg tccgtccgct ggaaaaacct aagctgatct
     7861 cttatccctg tgtttttgat atagtcgact ccacgtcacg caactgtgag agctgtgtgc
     7921 ttcgcacgtg tttcttctga cgacttggct tctttttctc tcggtcgcaa aatcctgcca
     7981 aacccttact atcgatctaa gtcctcctcg tcggcaccgt cgtcgccgtc gtcatcctcg
     8041 tctcttgccc tgccctccac acgatcaacc tgctctttcg ccagcgagaa ttgcaacaaa
     8101 agaccttcgc tcatgatcca tcgagccact gcacgaaggc ctgatgatga ctaatcatga
     8161 tatgaatcga ccggtcgtca gaaaaaagtt gggggtggtg cttagggtat gagcaacctt
     8221 ggtcgaaaag ccgtaataca gttcttcaga acgattccga ggaattttct tttttgcgca
     8281 aagatgatgt ttgatatcta actatagatt gacatattca agtggtacag aaatcgtagg
     8341 taggatgtga gaatgtcagg actaggaagt ttgcggcgtg cgagaatttg atcctgagtc
     8401 ctaaatcgtg tcggtgctaa tgactacgca gcgtaatcga aaaacagacc agagtggttt
     8461 cttcggcgac ttcccaagga atatcccgtc cactttgaag aactttatgg cgtgagttca
     8521 atcctacagg agtggtggat gcggtcatcg ttgcacaata aaaaggtaac ggaccgcttg
     8581 acgcgatgct gaaacatgat ctgactagaa gagaggaagt aagtcaggtg acttgagcgt
     8641 ggcaaattaa gtacctatgt aacaccctct aagtacagta aggtacggta actttcatta
     8701 gctcctacat gtttcaaaca aattcggaat cccctcgcat cccctcgccc tcgttttcgc
     8761 cctctcctat cctctcctct cctctcttct acacttcacc aattaaccca tagtacatac
     8821 tcccttcacc atgctaacat ctctattgac cgactcggtt ctgtttgaaa tagagagaca
     8881 ccccatttgg ctgcagctcc gactcgagaa cagagagtac ggagcgtacg gagtacaagg
     8941 tacggaaata cggagagcag ggaatctggc tcgcgctgca taggcgttcg ataccgattt
     9001 ctcagtcagt atgtaagcca ttctttcacg ccggcatgta ccatcttctc ctcgagaggt
     9061 ccgtagatag tgtttcggaa atatacctct aatgtctgca tagctccatg gctcatcaat
     9121 taggatttgg gcttgcttcg gcattttcag attggcctat cattgcctca gtagtcgagc
     9181 ctctgatgtt gtattccttt acactggtca ccatctagag caattttact ttaacatgtt
     9241 ttaccacggc ccggctgtgt gcaccagcac tgttctgtac ggataccgtc atctcaccgg
     9301 gcaccggcat tggtttccaa aatgtttcga cagagagaag acactcgggc atcagtttgg
     9361 catagcactg atgatctcca tggcctttag gacaagatta tcacaattct attttcacca
     9421 acgcccttgg tgatgttcac tgtcactctc cgtgcacttc tatgacgtct ttgtcgatgt
     9481 aatagctctc acttcagatt ctgattgtat aaaagagctc ggcgatgtcg aacttctttt
     9541 ttttcttttt tcttttttta caaaaaggta acgatcagga tttcacacaa ttgaattttg
     9601 ggcttcgata tttttgatca taccattctt ttcatgaata tggacttctt agtcttaaag
     9661 gaactgtgcc taaccctcca gaccgaattc tcccaactcg atctcgacgc tagtttcatc
     9721 catcatggtg gtcattctct caccgcggct gctctcgtgg ccgcatgcaa agcgcaaggc
     9781 tgtgaattga caactggaaa agtcctaaca agtgactcac tgcggaacct cattcactcc
     9841 gcacagccat gcgcgaagcc tgattctcca gacccggtgt ccaagcaagt ctctagcacc
     9901 tacatgggaa cgccctcgag agaatcttca atactctcaa agctatctcg aaacttgcgc
     9961 taccaaaacg ataacatgac ccccccggaa cccgatgact ttcttagtca aaaatcactc
    10021 actcttagtc cagtaaccct caatcaaata cggagccatg cgctagcgga ttctccctcc
    10081 ccatcacccg aaaggtcgtc gactcctaca tccattgaga tcacctcgac ccttaagagg
    10141 cattccattt cgagcccaca gcgtcttaat gcatcctcct tgggatctct ttcattcccg
    10201 gaacgtcatg acgataagct cacagagatg caactgtctc tgattcatgg tactcttaaa
    10261 accccaggaa tgaacataat cacccactgc gaaacatact attctcatta tattcccact
    10321 atgaaagcgg catggaagac cgtcgtcgag atggaaccga tatttcaagt cttgcctttg
    10381 aagaagtttc tcgaggaaga taggaaggta ttcgattggc gtgacgcaac tgcagtagag
    10441 gagggagacg aaaaagacgg aaaggggcta tgcgatgaga atcgtatcgg atcgttcttc
    10501 cgggttgttc cttgtacagt ggcgccgaag caactgagcc ggtcgaaaat tatttggata
    10561 gttcatcatt cccttattga tggctactcc gcttctcttg tgtttgataa agttcgaaga
    10621 gtggccaatg gaatgagcgt gcagcccggc cccccatttt cccggctggc cgaggacctc
    10681 agattatttc aacaatcaca tcgcgacgaa gggaatgctt attggctgaa aaagcttgaa
    10741 caaagcaacg atgccaagac tgagctactg ctaccttacg tggacgaaga tgctggccaa
    10801 gcacgaaacg ctgaggtagt cagcgatctt agctccgtcg ttgagaagct gagatcggcg
    10861 gctcgagata tgaacgttac gccagcagct ttctttaatg ctgcatgggc tttagttttg
    10921 gcaacatatg ctgattccga catggttgct tttggcgctg ttctctcggg acgaaattta
    10981 ccgttgccga acgtggctgc tgttgtggga ccgcttgtaa acactctccc tttatacgtc
    11041 aacatcaacc gaagcctctc tgtacaagaa tttgttcgct cggtctttga aaacctgatg
    11101 gagctagcag aatttcagtg gacgacgccc gagcatggat tttctcgcag tttcgagtct
    11161 gccttgtcca tgcaattcgg accgccagac cccctacagg ccgcagtaat gccgattgaa
    11221 agcccttaca cccaccaggc tacggaaatc ccactcagca tcgcggttga agcagatgga
    11281 aagcttcgat ttcaatatca tcgcaatcga ttcagcccga agaacattgg taaattggtc
    11341 tcatgttatg aggaggcgct gcagttgctg ctgcaggcac atgcaaccgt cgatgcgaca
    11401 atggagggac tgctctcatg tccctccaaa gcagtattgg ggagatacgg aaactgtttc
    11461 tctgggttga caaccaaaac gtctgtcaaa cgtgacttgg tgactctttt tgaagcgacg
    11521 gcgcagaaat ttccagatga cattgccatt gaaagaggag acttttccat cacttatcga
    11581 gattttgacc acgtttctag tcggttagct ttgcgactca cgcgcctcat ctctacaggc
    11641 gatgtcgttt gtgttcattc ggatcgatca gttaattggc ttattgccat ctacagcatt
    11701 ctgaaagctg gaggagtata ctgttcgttg gacagtgcct tacctcctga cctccgaaat
    11761 tcaatgtatt cacttgctga tgcaaaggtc tatttgaccc cttcaacatc gcaactgcac
    11821 ttaaccccag ttgattgtga attatacatg tcggttgaaa gtgccctaag cgagttcgat
    11881 gacccagaag taggagtctt ggagcaccga cagcagccaa tgccatcgtc aacggcctac
    11941 ttatgcttta cttctggttc gactggcacg ccgaaaggcg ttctctgtac ccacgagggt
    12001 cttgttgctt ttcagagcga cctggaagtt cgactgttcg ctcaacccgg aaagaaaatc
    12061 tcccagatta tgtcagctgc ctttgacggg agcatccatg agctattctc cgcacttagt
    12121 tatggtgcta ctctggtttt acaagcaggt ggagacccgt ttgcacacct tcattcagtt
    12181 gactcagcca ttctgactcc ttcaatcgct cgtgttttaa acccggaaga ctttaagcgt
    12241 ctaagcacgg tgggtgtaga agcatttttt ccaaaagcta cttagcgcta acacacgaag
    12301 taggtctact tggtgggcga gcctgtgcca caagctgtcg ctgataagtg gagcaaccac
    12361 aagcagttgt acaacatgta cggaccaact gaaggaacct gtggagctac gattaagcgc
    12421 ctaaaccctg caagtccggt cacaattgga ggcccgaatc ctaccacccg aatatactta
    12481 ctaaattctc gcaaagacat ggtgctgcca ggcatgattg gagaaatcta cttagctgga
    12541 gttcaaattg ccaaaggcta tctcaaccta ccgactgaga caaaggacag attcttaccg
    12601 gacacaatat gccgcaatgg ggagcagatg tacaagacgg gagacagagg ctactggaat
    12661 gagctgggtg aaatcgtctg tcttggtcgt aatgatcgac agatcaagct ccgcggctat
    12721 aggttggata tgaatgatct tgaaattcgc attgccaagg ctatgcccac gatggaaggg
    12781 attgcaatct ctcgccgagg agaccaccta gtcgccatgg ttcaacctgc gtcgatgaac
    12841 accaaagatc ttctttcgag ggtagcaaaa gttataccct cgtatgctat tccacagcag
    12901 ataaccgcag tggaccgact acccaccacc tcggcaggta agatagatta tgctgcagtg
    12961 agccgcaata gcattgggag tccgacttgt caaaaaggcg ctcccagaac agcaaccgag
    13021 agagcagtgg ctagtgtatt caattctgtt ttaaatctag gtgaggggac cagagtaact
    13081 ttgggatcca gctttgtcga tcttggcggg cattctctac aacaactttc cctagccaag
    13141 catttgacaa gaatctttga tcttcagata ccattgcggt tgataattga acgtccggcg
    13201 ctcggagagt tggcaaaagg catcgacgat cataaggcca caaacaagcc tgcaatgcca
    13261 cctgcccact ccctgggcca acagcaggtt tcgccaatcg agaaggaatg gctgcagaag
    13321 tatgatgttg atgcaggttc ttcctgcttc aacgtcgcct tcatctccag ttttgccgaa
    13381 gagaccgtcg accgctacgt gctagcagag gcttggaaca cagtattggc aaggcataag
    13441 ctgctgcgca gcaaatatgt tcctcgtcgt gcaagacccc ctttacgatc ttatgcgagt
    13501 tgcgcgcctc aggcacaacg agtaggaaat ctggatttat ggactgaagt gaaccgccct
    13561 tttcaggttg gccgcacgaa tcctgcacga gtaactgtca cgaaagacag attgatcgtc
    13621 gtcctgagtc acatcgtggc agattacaca accttggcta tcctcctgcg ggaagcttcg
    13681 gcggtctata atgggcaaca gcttgaacca atttcgcgaa gctattccga cgtcgacgtc
    13741 tggtatcgca acgtgccccc gtgctatttg gatttttggt ccacttttct caaagactgt
    13801 cccgacagcc ccccgctgct agggaggcac caagagcgca gtggatgtcg tggtgtatcg
    13861 acggtgtcct cgattgatag tcacgctttt caggaaatgt tgcaatactc ccactccgcc
    13921 aaggtttccc ttcagcagct cgtcacagga gctgtggcaa tatgtctgca gctggactca
    13981 cctgagactg atattgtcat tggaaacccg tatatgaatc gcaattcgga cgaagatctt
    14041 gagacggtag gcttgtttct agagccactt ccagtaagga tcaagtatgg ccttggaccc
    14101 gacgaaacat ccgacgacat accggagacg tatatgcaag ccgtgcagag atccagccaa
    14161 gcagctcttg cgaacgcgat gccttggcac cggcttctag accatctctc catacatccg
    14221 acctatcccg accatccact tctggacgtc atggtcagct tccacgatta ccgccaatcg
    14281 ctcgacctga aaatggcggg gcccgacttc gagagctgtt tcgtctggtc ggaggggtcc
    14341 aaattcaagc tcatgtgcga gttcaccgtt atctccgaca ccaagctcct gctgcggctc
    14401 gaacacgaca ccgaatgcat ctcagccgcc gagatccagc gcatccaaac cttaatcccg
    14461 caagccctgt cgcttcttag tcagagcatt ccgcacaacg aactcaaacg gcggcttttc
    14521 gccggcgagg aaccgacgtg ccaccaggtc atggataccg accagctatt tggtacgaga
    14581 ctctgcgata ttgagtagag gtccgacaaa agaacaagag gaggggggct gggttcatct
    14641 caagattaga tggaagagaa ggcatttgta tttcccccaa cgcggcagca cctaaactca
    14701 tcatttaaaa gaaaaatctt tggatttaga gcttgcgaaa aagatttttt tacccccctc
    14761 tgcccttaga catgacacgg aagattaaaa aagccagctc ataaaatata tagaataaaa
    14821 atagaagggc aaaagaaaac agaaacaccc ccaatctagt agcaccttct tgatacaaaa
    14881 cacccccccc gtgaaccacg tatttaacac aattccctca attcaacttc cccccccccc
    14941 tctctttttt ccaaaaatct cgtccccctc taactctctc acaaaagaaa acccccaaaa
    15001 catccttcgc tccccccgct ttccccaggg ctggtctata ggattatttc cccccccctt
    15061 tcccgggttt cttattccct aaaaacccac ccccaatcct ccccgggttt caagttttgt
    15121 cctaacaaca aaccccccgc cgtt
//
